Dutase is a mixture of two drugs: dutasteride and tamsulosin. hydrochloride These drugs have complementary mechanisms of action, so the rate of urination decreases rapidly. It can reduce the risk of urinary retention. The pharmacodynamic response to the fixed-dose combination of dutasteride and tamsulosin is not expected to differ from the pharmacodynamic response obtained with the simultaneous use of dutasteride and tamsulosin as separate components. Dutasteride inhibits the activity of isozymes type I and II. DHT is an androgen that causes prostate enlargement and BPH. It inhibits the activity of adrenergic receptors.